hrp0092p2-212 | Multisystem Endocrine Disorders | ESPE2019

Unusual Ovary Formation in a Girl with McCune-Albright Syndrome

Makazan Nadezhda , Orlova Elizaveta , Artemova Alla , Vladimirova Victoria , Vorontsov Aleksandr , Kareva Maria , Peterkova Valentina

McCune-Albright syndrome (MAS) is a rare disorder caused by somatic mutations in GNAS gene leading to fibrous dysplasia (FD), cafe-au-lait spots and hyperfunctioning endocrinopathies. The common feature of MAS in girls is peripheral precocious puberty (PP) with the recurrent ovary cysts. Few cases of ovary tumors have been described to date.8,5 year-old girl with MAS is closely observed in our centre since the age 4,5, when the diagnosis was est...